Columbia Skincare patent pending probiotics formula is the world's first for topical skin use. It contains probiotics ('good bateria') plant stem cells and peptides (amino acids) that uniquely combine to enhance the skin's natural ability to renew itself. -source: Columbia Skincare Regeneration is one of the most important biological factors in minimizing the effects of aging on the skin, Columbia Skincare probiotic ingredients work together with the body's endocrine, lymphatic, circulatory, integumentary and immune systems. The result is healthier, more radiant and luminous skin with reduced signs of aging. - source: Columbia skincare This Probiotic Concentrate serum is designed to be used both day and night. When I applied the Probiotic concentrate serum and cream, I can immediate feel my skin working. It felt tighter and softer immediately upon application and throughout the day. I like the ver...